What medicine is best for liver cancer chemotherapy?
Liver cancer is one of the common malignant tumors in the world, especially for patients with advanced liver cancer, chemotherapy is one of the important treatments. With the advancement of medical research, a variety of chemotherapy drugs are used for the treatment of liver cancer, but the selection of appropriate drugs depends on the patient's specific situation and the doctor's advice. This article will combine the hot medical topics of the past 10 days to give you a detailed introduction to the commonly used drugs and their effects in liver cancer chemotherapy.
1. Commonly used drugs for liver cancer chemotherapy
Chemotherapy drugs for liver cancer mainly include traditional chemotherapy drugs and targeted drugs. The following are some common drugs and their characteristics:
| Drug name | Mechanism of action | Indications | Common side effects |
|---|---|---|---|
| Doxorubicin | Inhibit DNA replication and destroy tumor cells | advanced liver cancer | Cardiotoxicity, myelosuppression |
| Cisplatin | Destroy DNA structure and prevent cancer cells from dividing | liver cancer combined chemotherapy | Nephrotoxicity, nausea and vomiting |
| Oxaliplatin | Inhibit DNA synthesis and block tumor growth | Second-line treatment for liver cancer | Neurotoxicity, allergic reactions |
| Sorafenib | Targeted inhibition of tumor angiogenesis | First-line drugs for advanced liver cancer | Hand-foot syndrome, hypertension |
| Lenvatinib | Multitarget tyrosine kinase inhibitors | First-line treatment of liver cancer | Fatigue, proteinuria |
2. Selection of chemotherapy regimen for liver cancer
Liver cancer chemotherapy regimens need to be comprehensively determined based on the patient’s liver function, tumor stage and physical condition. Here are some common chemotherapy options:
| chemotherapy regimen | drug combination | Applicable people | efficient |
|---|---|---|---|
| FOLFOX solution | Oxaliplatin+5-FU+leucovorin | Advanced liver cancer with good liver function | About 20%-30% |
| GEMOX solution | Gemcitabine + oxaliplatin | Inoperable liver cancer patients | About 15%-25% |
| Sorafenib single agent | Sorafenib | First-line treatment for advanced liver cancer | Extend survival by 2-3 months |
| Lenvatinib single agent | Lenvatinib | First-line treatment of liver cancer | Equivalent to sorafenib with fewer side effects |
3. Precautions for liver cancer chemotherapy
1.Liver function assessment: Liver cancer patients are often accompanied by cirrhosis or liver function damage. Liver function needs to be evaluated before chemotherapy to avoid drugs aggravating liver damage.
2.side effect management: Chemotherapy drugs may cause side effects such as nausea and bone marrow suppression, and require symptomatic treatment such as antiemetics and leukocyte-raising drugs.
3.individualized treatment: Selecting targeted drugs based on genetic testing results can improve treatment effects.
4.combination therapy: Chemotherapy can be used in combination with interventional therapy (such as TACE) and immunotherapy (such as PD-1 inhibitors) to improve the efficacy.
4. Recent hot research on liver cancer treatment
1.Immunotherapy progress: PD-1/PD-L1 inhibitors (such as nivolumab) have shown potential in the treatment of liver cancer, and some patients can achieve long-term survival.
2.New targeted drugs: Regorafenib and Cabozantinib are approved for second-line treatment of liver cancer, providing patients with more choices.
3.precision medicine: Monitor tumor gene mutations through liquid biopsy to guide individualized medication.
Summary
The selection of chemotherapy drugs for liver cancer needs to comprehensively consider efficacy, side effects and patient tolerance. Traditional chemotherapy drugs (such as doxorubicin, oxaliplatin) and targeted drugs (such as sorafenib, lenvatinib) are the main choices, while immunotherapy and new targeted drugs have brought new hope to patients with liver cancer. Patients should develop a personalized treatment plan under the guidance of a doctor, and closely monitor treatment response and side effects.
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